Potential cytoprotective activity of ozone therapy in SARS-CoV-2 / COVID-19

The "Antioxidants" Journal (impact factor 4,520) Publishes a Paper on Ozone Therapy and COVID-19 The paper "Potential cytoprotective activity of ozone therapy in SARS-CoV-2 / COVID-19" has been published by the journal "Antioxidants" as part of the "Special Issue Antioxidant and Cytoprotective". Paper written by: Gregorio Martínez, AEPROMO member and president of ISCO3 (International Scientific Committee of Ozone Therapy), Adriana Schwartz, president of AEPROMO and scientific secretary of ISCO3 (International Scientific Committee of Ozone Therapy), and Vincenzo Di Donna. "Antioxidants" (ISSN 2076-3921; CODEN: ANTIGE), is an indexed scientific and peer review journal, with an impact factor of 4.520. Free of charge access to the paper: Abstract : https://www.mdpi.com/2076-3921/9/5/389 PDF Version: https://www.mdpi.com/2076-3921/9/5/389/pdf


(1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κ B/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κ B/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed. Keywords: ozone therapy 1; SARS-CoV-2; Keap1/Nrf2/ARE pathway; NF-κ B; Nrf2

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